The three detectives make a formidable team, solving a series of seemingly impossible crimes which expose the dark underbelly of the city - from a priceless art theft, high-stakes kidnapping and a decades-old unsolved murder, to a gruesome subterranean prison and corruption and bribery at the highest levels of power.
But it's not long before their headline-grabbing breakthroughs, unconventional methods - and untraceable pasts - attract the attention of the NYPD and the FBI.
After all, it's no surprise that there's a mystery or two to unravel in the city that never sleeps . . . not least, who really are Holmes, Margaret and Poe?
