At an early age Hyakkimaru's father offered forty eight of the child's body parts to a cadre of demons in return for power and fortune. Now the blind, mute boy embarks on a quest to reclaim what will make him whole again. Slaying a never-ending series of demonic beasts and ghouls, Hyakkimaru, accompanied by a young thief named Dororo, crosses the country only to find that humanity may be the true monsters they fear.